Table 2.

Levels of NDEV proteins/peptides in patients with AD and NCs.

	AD N = 31	NC N = 15	t	P
CD81 (ng/mL)	4.91 ± 1.426	6.27 ± 1.580	−2.917	0.006
Aβ42 (pg/mL)	8.64 ± 6.037	5.40 ± 1.700	2.027	0.049
P‐S396‐tau (pg/mL)	4.25 ± 1.474	4.38 ± 1.135	−0.299	0.766
P‐T181‐tau (pg/mL)	34.68 ± 15.198	26.68 ± 9.816	2.049	0.047
IL‐6 (pg/mL)	1.32 ± 1.220	1.08 ± 0.787	0.683	0.498
MMP‐9 (ng/mL)	4.11 ± 3.006	1.60 ± 1.078	4.146	<0.001

Values are provided as mean ± SD. The differences in NDEV protein/peptide levels between patients with AD and NCs were determined by independent two sample t‐test. Abbreviations: NDEV, neuronally derived extracellular vesicle; AD, Alzheimer’s disease; NC, normal control; IL‐6, interleukin 6; MMP‐9, matrix metalloproteinase‐9.