Table 1.
Demographic and clinical data
| Variable | Summary (N=855) |
|---|---|
| Age at PD onset (years) | 64 (22, 94) |
| Sex (male) | 548 (64.1%) |
| Initial visit | |
| Age (years) | 69 (28, 97) |
| Disease duration (years) | 3 (0, 38) |
| Medication includes levodopa | 394 (46.1%) |
| Good levodopa responsivity | 362 (91.9%) |
| Bradykinesia | 818 (95.7%) |
| Rigidity | 819 (95.8%) |
| Postural instability | 181 (21.1%) |
| Resting tremor | 590 (69.0%) |
| Postural tremor | 199 (23.3%) |
| Kinetic tremor | 61 (7.1%) |
| Dementia | 4 (0.5%) |
| Dystonia | 83 (9.7%) |
| Dyskinesia | 87 (10.2%) |
| Autonomic dysfunction (GI, UG) | 519 (60.7%) |
| Impulse control disorder | 9 (1.1%) |
| (Pseudo‐)hallucinations | 43 (5.0%) |
| Depression | 261 (30.5%) |
| Orthostatic hypotension | 61 (7.1%) |
| REM sleep behavior disorder (RBD) | 91 (10.6%) |
| Restless legs syndrome (RLS) | 42 (4.9%) |
| Most recent visit | |
| Age (years) | 72 (28, 98) |
| Disease duration (years) | 6 (0, 48) |
| Medication includes levodopa | 681 (79.6%) |
| Good levodopa responsivity | 656 (96.3%) |
| Bradykinesia | 834 (97.5%) |
| Rigidity | 828 (96.8%) |
| Postural instability | 265 (31.0%) |
| Resting tremor | 545 (63.7%) |
| Postural tremor | 106 (12.4%) |
| Kinetic tremor | 34 (4.0%) |
| Dementia | 62 (7.3%) |
| Dystonia | 116 (13.6%) |
| Dyskinesia | 194 (22.7%) |
| Autonomic dysfunction (GI, UG) | 626 (73.2%) |
| Orthostatic hypotension | 118 (13.8%) |
| Impulse control disorder | 16 (1.9%) |
| (Pseudo‐)hallucinations | 107 (12.5%) |
| Depression | 308 (36.0%) |
| REM sleep behavior disorder (RBD) | 104 (12.2%) |
| Restless legs syndrome (RLS) | 55 (6.4%) |
| Survival information | |
| Death | 316 (37.7%) |
| Follow‐up length after PD onset (years) | 8 (1, 48) |
| PD subtype | |
| TD | 371 (43.4%) |
| AR | 241 (28.2%) |
| GD | 88 (10.3%) |
| Mixed | 155 (18.1%) |
| Rapid progression | 262 (41.4%) |
| Dementia within 5 year of onset | 35 (6.3%) |
| Falling within 5 years of onset | 231 (37.0%) |
| Become dependent on a caregiver within 5 years of onset | 51 (9.0%) |
TD, tremor dominant; AR, akinetic‐rigid; GD, Gait difficulty; GI, gastrointestinal; UG, urogenital.
The sample median (minimum, maximum) is given for continuous variables. Information was available regarding rapid progression for n = 633 patients; information on dementia within 5 years of PD onset was available for n = 557, on falling within 5 years of PD onset for n = 625, and on becoming dependent on another person within 5 years of PD onset for n = 566 patients. Information on rapid progression was unavailable for n = 222 patients due to the combination of absence of these three characteristics and insufficient follow‐up length. Survival information was available for n = 838 patients.