Table 1:
Baseline characteristics of 1,035 childhood- and adult- onset SLE patients enrolled in Lupus Outcome Study
| cSLE(N=113) | aSLE(N=922) | P | |
|---|---|---|---|
| Sociodemographics | N (%) or Mean ± SD or median (range) | ||
| Age at baseline BILDa score, years | 32±10 | 50±13 | <0.001 |
| Age at diagnosis, years | 14±3 | 36±12 | <0.001 |
| Sex, female | 100 (88%) | 855 (93%) | 0.1 |
| Ethnicity, non white | 67 (59%) | 367 (40%) | 0.001 |
| SLE Characteristics | |||
| Disease duration at baseline BILD, years | 16 (4,50) | 13 (0,49) | <0.001 |
| Dialysis ever | 22 (19%) | 73 (8%) | <0.001 |
| Renal transplant ever | 19 (17%) | 44 (5%) | <0.001 |
| History of lupus nephritisb | 67 (59%) | 232 (25%) | <0.001 |
| Cyclophosphamide use ever | 28 (25%) | 144 (16%) | 0.01 |
| Steroid use ever | 112 (99%) | 749 (95%) | 0.07 |
| Steroid-associated variables | |||
| Cataract | 28 (25%) | 404 (44%) | <0.001 |
| Osteoporosis with Fracture | 13 (12%) | 169 (18%) | 0.07 |
| Avascular necrosis | 16 (14%) | 72 (8%) | 0.02 |
| Diabetes | 9 (8%) | 123 (13%) | 0.1 |
a
BILD= Brief Index of Lupus Damage
b
Met ACR SLE criteria for nephritis at study entry