Figure 2.

Structure and Function of Neuropilin 1. Neuropilin 1 (Nrp1) is a cell surface receptor composed of an A1, A2, B1, B2, C, transmembrane (TM), and a C-terminal (C) domain. The C-terminal domain contains a SEA motif which binds PDZ adaptor proteins. The A1 and A2 domains are responsible for binding semaphorins while the B1 and B2 domains have been characterized to bind VEGF, TGFβ, PlGF, and HGF. The C domain is an oligomerization domain, which allows Nrp1 to interact with its various co-receptors and amplify signaling via their associated ligands.