Table 3:
Potency of compounds for select serine proteases following 30 minute incubations
| IC50 values (nM) with 95% Confidence Interval Values | ||||
|---|---|---|---|---|
| Name (Analog Number) | Elastase | Chymotrypsin | Trypsin | Proteinase K |
| Tutuilamide A (1) | 1.18 (0.33 – 1.97) | 1014 (853.0 –1227) | >20,000 | 103.7 (84.6 – 129.2) |
| Tutuilamide B (2) | 2.05 (1.68 – 2.46) | 576.6 (447.0 – 767.3) | >20,000 | 87.6 (65.2 – 122.2) |
| Tutuilamide C (3) | 4.93 (2.72 – 7.48) | 542.0 (445.0 – 671.2) | >20,000 | >5,000 |
| Lyngbyastatin 7 | 11.50 (9.25 – 14.28) | Not Done | Not Done | 1574 (806.0 to >5,000) |
| Symplostatin 2 | 5.41 (4.30 – 6.69) | Not Done | Not Done | 216.5 (155.2 – 326.0) |
| Tutuilamide A-linear (5) | 3,080 (2371 – 4248) | Not Done | Not Done | >5,000 |
| Tutuilamide A-methyl (6) | 1.83 (1.56 – 2.12) | Not Done | Not Done | 98.6 (94.4 – 100.1) |