Table 2.

Primary and secondary outcomes for total cohort and stratified by management

Outcome	Weight pooled risk in % (95% CI)
	Total cohort	LMWH	VKA	Other	None
(A) Pooled outcomes after 6 months of follow-up and stratified by initial management
Recurrent VTE	5.8 (3.7–8.3)	6.2 (3.5–9.6)	6.4 (2.2–12)	4.3 (3.3–12)	12 (4.7–23)
Major hemorrhage	4.7 (3.0–6.8)	3.9 (2.3–5.9)	13 (6.4–20)	6.4 (0.2–20)	6.4 (1.3–15)
Mortality	37 (28–47)	37 (29–44)	28 (18–40)	58 (38–77)	47 (28–66)

Outcome	Incidence rate per 100 patient-years (95% CI)
	LMWH	VKA	Other	None
(B) Incidence rates per 100 patient-years and stratified by management based on a per-protocol analysis
Recurrent VTE	12 (8.3–17)	9.8 (2.0–29)	9.5 (0.24–53)	30 (8.2–77)
Major hemorrhage	10 (6.6–15)	26 (11–52)	18 (2.2–66)	4.6 (0.55–17)

VTE, venous thromboembolism; DVT, deep vein thrombosis; PE, pulmonary embolism; CI, confidence interval.