FIG. 4.

Microglia-targeting nanoparticle design criteria. To achieve modulation of neurodegeneration associated with microglia-induced neuroinflammation, nanoparticles should be designed incorporating¹ microglial receptor-targeting ligands taking advantage of microglia's phagocytic nature,² therapeutic agents for inhibition of microglial activation and toxic protein aggregation, and³ biodegradable materials with low immunogenicity,⁴ without compromising the nanoparticle size and serum stability.