. Author manuscript; available in PMC: 2020 Sep 9.

Published in final edited form as: Mol Carcinog. 2019 Nov 12;59(1):104–115. doi: 10.1002/mc.23132

TABLE 1.

Combined analysis of the two unfavorable SNPs in PLCO and HLCS datasets

SNP	Allele^a	Gene	PLCO (n=1,185)				HLCS (n=984)			Combined analysis
SNP	Allele^a	Gene	EAF	HR (95% CI)^b	P^b	BFDP	EAF	HR (95% CI)^c	P^c	HR (95% CI)^d	P^d	P_het^e	I ²
rs13213007	GG>A	HDAC2	0.26	1.18 (1.05–1.32)	0.004	0.58	0.29	1.14 (1.02–1.29)	0.022	1.16 (1.07–1.26)	0.0003	0.758	0
rs60571065	TT>A	PPARGC1A	0.11	1.22 (1.04–1.43)	0.015	0.77	0.10	1.21 (1.00–1.46)	0.050	1.22 (1.08–1.37)	0.002	0.948	0

Abbreviations: PLCO, Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial; HLCS, Harvard Lung Cancer Susceptibility Study

Major > minor allele;

Adjusted for age, sex, stage, histology, smoking status, chemotherapy, radiotherapy, surgery, PC1, PC2, PC3 and PC4;

Adjusted for age, sex, stage, histology, smoking status, chemotherapy, radiotherapy, surgery, PC1, PC2 and PC3;

in fixed-effect model;

P value for heterogeneity by Cochrane’s Q test.