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. 2020 Sep 9;11:4520. doi: 10.1038/s41467-020-18298-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a Heatmap showing statistically significant (P < 0.05) association between collagen mRNA expression in pre-treatment tumor biopsies and disease progression (progressive disease vs. partial/complete response) for melanoma patients receiving anti-PD-1 therapy (nivolumab). b Representative dot plots comparing pre-treatment collagen mRNA levels in melanoma patients that exhibited progressive disease (PD) versus partial or complete response (PR/CR) to anti-PD-1. PD sample size of n = 13 independent patient samples and PR/CR sample size of n = 15 independent patient samples. Boxplots shown as the median ± 1 quartile, with whiskers extending to the most extreme data point within 1.5 interquartile range from the box boundaries. Statistics calculated using two-sided Wilcoxon matched pair rank test with significance at P < 0.05. c Overall changes in LAIR1 and HAVCR2 (TIM3) mRNA expression levels in melanoma tumor biopsy samples between pre- and on-treatment with anti-PD-1; n = 43 independent patient samples for pre- and on-treatment groups. Boxplots shown as the median ± 1 quartile, with whiskers extending to the most extreme data point within 1.5 interquartile range from the box boundaries. Statistics calculated using two-sided Wilcoxon matched pair rank test with significance at P < 0.05. d Kaplan–Meier curves predicting survival of melanoma patients receiving anti-PD-1 therapy based on net changes in LAIR1 and HAVCR2 (TIM3) mRNA levels. Statistics calculated using a two-sided log-rank Cox test with significance at P < 0.05.