Table 1.
Association (Beta) between polygenic scores (genomic, genic, intergenic and gene-sets) and subcortical volumes averaged across hemispheres.
| Thalamus | Caudate | Putamen | Pallidum | Accumbens | Hippocampus | Amygdala | |
|---|---|---|---|---|---|---|---|
| PRS Pt=0.05 | β (p) | β (p) | β (p) | β (p) | β (p) | β (p) | β (p) |
| Genomic | −0.006 (0.41) | −0.015 (0.10) | −0.012 (0.19) | −0.013 (0.17) | −0.006 (0.51) | −0.007 (0.45) | −0.008 (0.34) |
| Genic | −0.008 (0.26) | −0.013 (0.13) | −0.012 (0.19) | −0.010 (0.29) | −0.007 (0.47) | −0.007 (0.44) | −0.006 (0.49) |
| Intergenic | −0.001 (0.87) | −0.014 (0.15) | −0.018 (0.05) | −0.016 (0.09) | −0.011 (0.25) | −0.008 (0.37) | −0.021 (0.02) |
| 5HT2C | 0.004 (0.63) | −0.003 (0.75) | −0.005 (0.57) | −0.006 (0.54) | −0.007 (0.46) | −0.002 (0.82) | 0.007 (0.43) |
| abnormal_beh | −0.030 (0.00005)* | −0.014 (0.10) | −0.004 (0.68) | 0.003 (0.75) | −0.003 (0.73) | −0.013 (0.12) | −0.001 (0.87) |
| abnormal_ltp | −0.007 (0.32) | −0.016 (0.07) | −0.007 (0.42) | 0.01 (0.29) | −0.002 (0.83) | −0.001 (0.88) | 0.005 (0.55) |
| abnormal_nse | 0.010 (0.19) | −0.014 (0.10) | −0.012 (0.18) | −0.003 (0.75) | −0.004 (0.69) | 0.006 (0.50) | 0.001 (0.95) |
| CaV2 channels | 0.002 (0.78) | −0.001 (0.90) | −0.000 (0.97) | 0.008 (0.41) | −0.009 (0.35) | 0.004 (0.64) | 0.003 (0.75) |
| FMRP targets | −0.019 (0.01) | −0.010 (0.27) | 0.011 (0.21) | 0.019 (0.04) | −0.004 (0.66) | −0.021 (0.01) | −0.002 (0.82) |
| LoF intolerant | −0.016 (0.03) | 0.002 (0.82) | −0.002 (0.84) | 0.002 (0.82) | 0.011 (0.26) | −0.011 (0.19) | −0.002 (0.85) |
P values reported in this table are uncorrected. Nominally significant associations are highlighted in italic. Significant associations after FDR correction (7 tests for genomic PRS, 14 for genic/intergenic PRS, 49 for gene−set PRS) are highlighted with an asterisk. 5HT2C: 5−HT2C receptor complex genes set; abnormal_beh: abnormal behaviour genes set; abnormal_ltp: abnormal long term potentiation genes set; abnormal_nse: abnormal nervous system electrophysiology; CaV2 channels: voltage-gated calcium channel complexes genes set; FMRP targets: targets of fragile X mental retardation protein genes set; LoF intolerant: loss of function intolerant genes set.