Table 2.
Association between polygenic scores (genomic, genic, intergenic and gene−sets) and subcortical volumes for left and right hemispheres separately.
| Thalamus | Caudate | Putamen | Pallidum | Accumbens | Hippocampus | Amygdala | |
|---|---|---|---|---|---|---|---|
| PRS Pt=0.05 | β (p) | β (p) | β (p) | β (p) | β (p) | β (p) | β (p) |
| Left hemisphere | |||||||
| Genomic | −0.005 (0.52) | −0.017 (0.05) | −0.019 (0.04) | −0.008 (0.43) | −0.009 (0.37) | −0.014 (0.12) | −0.008 (0.39) |
| Genic | −0.004 (0.65) | −0.018 (0.05) | −0.020 (0.03) | −0.006 (0.53) | −0.009 (0.34) | −0.010 (0.26) | −0.005 (0.60) |
| Intergenic | −0.004 (0.64) | −0.014 (0.12) | −0.019 (0.04) | −0.011 (0.28) | −0.014 (0.16) | −0.010 (0.28) | −0.012 (0.18) |
| 5HT2C | 0.010 (0.23) | −0.000 (0.96) | −0.007 (0.44) | −0.004 (0.65) | −0.011 (0.23) | −0.002 (0.86) | 0.001 (0.91) |
| abnormal_beh | −0.020 (0.01) | −0.013 (0.15) | −0.010 (0.26) | 0.002 (0.81) | −0.010 (0.27) | −0.011 (0.19) | −0.012 (0.16) |
| abnormal_ltp | −0.008 (0.33) | −0.013 (0.14) | −0.008 (0.36) | 0.006 (0.55) | 0.003 (0.73) | 0.004 (0.68) | −0.002 (0.82) |
| abnormal_nse | −0.004 (0.58) | −0.017 (0.06) | −0.013 (0.15) | −0.003 (0.74) | −0.001 (0.88) | 0.004 (0.61) | −0.011 (0.22) |
| CaV2 channels | 0.005 (0.54) | −0.005 (0.61) | −0.002 (0.82) | 0.005 (0.63) | −0.003 (0.75) | −0.003 (0.73) | −0.000 (0.98) |
| FMRP targets | −0.017 (0.03) | 0.004 (0.63) | 0.005 (0.59) | 0.017 (0.09) | −0.005 (0.57) | −0.015 (0.08) | −0.004 (0.64) |
| LoF intolerant | −0.010 (0.21) | −0.001 (0.90) | −0.008 (0.38) | −0.000 (0.97) | 0.011 (0.24) | −0.007 (0.39) | −0.003 (0.76) |
| Right hemisphere | |||||||
| Genomic | −0.008 (0.30) | −0.013 (0.14) | −0.002 (0.86) | −0.022 (0.02) | −0.009 (0.35) | −0.010 (0.25) | −0.013 (0.12) |
| Genic | −0.009 (0.21) | −0.014 (0.11) | −0.003 (0.70) | −0.018 (0.04) | −0.003 (0.74) | −0.006 (0.48) | −0.005 (0.60) |
| Intergenic | −0.001 (0.88) | −0.013 (0.16) | −0.010 (0.25) | −0.015 (0.09) | −0.015 (0.12) | −0.010 (0.27) | −0.023 (0.009) |
| 5HT2C | 0.006 (0.41) | −0.002 (0.80) | −0.004 (0.65) | −0.000 (0.98) | −0.008 (0.41) | −0.002 (0.82) | 0.010 (0.24) |
| abnormal_beh | −0.031 (0.00005)* | −0.008 (0.34) | 0.004 (0.65) | −0.000 (0.96) | 0.004 (0.70) | −0.014 (0.11) | 0.010 (0.26) |
| abnormal_ltp | −0.009 (0.26) | −0.018 (0.04) | −0.018 (0.04) | 0.001 (0.93) | −0.003 (0.73) | −0.002 (0.80) | 0.011 (0.22) |
| abnormal_nse | −0.010 (0.19) | −0.008 (0.35) | −0.005 (0.59) | 0.002 (0.84) | −0.005 (0.56) | 0.003 (0.75) | 0.017 (0.05) |
| CaV2 channels | −0.004 (0.56) | 0.004 (0.68) | 0.009 (0.32) | 0.009 (0.32) | −0.009 (0.35) | −0.001 (0.95) | −0.000 (0.96) |
| FMRP targets | −0.015 (0.06) | 0.009 (0.29) | 0.004 (0.64) | 0.008 (0.38) | −0.001 (0.89) | −0.016 (0.06) | −0.005 (0.56) |
| LoF intolerant | −0.010 (0.19) | 0.009 (0.29) | 0.006 (0.50) | −0.006 (0.53) | 0.015 (0.12) | −0.011 (0.21) | 0.001 (0.91) |
P values reported in this table are uncorrected. Nominally significant associations are highlighted in italic. Significant associations after FDR correction (14 tests for genomic PRS, 28 for genic/intergenic PRS, 98 for gene-set PRS) are highlighted with an asterisk. 5HT2C: 5-HT2C receptor complex genes set; abnormal_beh: abnormal behaviour genes set; abnormal_ltp: abnormal long term potentiation genes set; abnormal_nse: abnormal nervous system electrophysiology; CaV2 channels: voltage-gated calcium channel complexes genes set; FMRP targets: targets of fragile X mental retardation protein genes set; LoF intolerant: loss of function intolerant genes set.