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. 2020 Sep 9;10:14809. doi: 10.1038/s41598-020-71830-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Model-simulated relative change of apparent central haematocrit (HCT) induced by a 4 h haemodialysis procedure (with the priming saline infused to the patient) as a function of the time of starting the measurements with respect to the beginning of the procedure (solid line) compared with virtual HCT changes equivalent to the actual relative blood volume (RBV) changes simulated by the model from a given moment of time (dotted line).