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. 2020 Sep 9;10:14852. doi: 10.1038/s41598-020-71684-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cumulative incidence of ≥ 40% decline in CKD-EPI eGFR and death (A) and doubling of serum creatinine and death (B) stratified by plasma sTNFR1 quartile over the study period. Cumulative incidence of events of interest (≥ 40% decline in CKD-EPI eGFR and doubling of serum creatinine) and the competing risk of death were calculated using the cuminc function in the R package cmprsk. Cumulative incidence plots were generated using ggcompetingrisks from the R package survminer. Panels are labelled by baseline plasma sTNFR1 quartiles 1, 2, 3, and 4, respectively. The cumulative incidence of renal outcomes over the study period is depicted by the red lines; the cumulative incidence of the competing risk of death is represented by the blue lines. In plasma sTNFR1 quartiles 3 and 4, the competing risk of death occurred more commonly than renal outcomes including ≥ 40% decline in CKD-EPI eGFR and doubling of serum creatinine.