Figure 2.

Liver-Specific Induction of the Transcription of Genes Encoding Enzymes Involved in the Biosynthesis of PUFA under Systemic DHA-PL Deficiency

(A–C) Samples were prepared from 1-week-old Agpat3 WT and KO mice. (A) Heatmap shows the rational differences in each PL species in various tissues (% of total area in WT/% of total area in KO, n = 3 for each group). Br, brain; WAT, white adipose tissue; BAT, brown adipose tissue; Li, liver; He, heart; Ki, kidney; SI, small intestine. (B) Relative mRNA expression of genes involved in the biosynthesis of PUFA in various tissues (n = 3 for each group). The expression data of the liver are identical to Figure 1G. Significance is based on two-way ANOVA followed by Bonferroni's post-hoc test (∗∗p < 0.01). (C) Percentages of PC species in the plasma with different number of cumulative double bonds (n = 3 for each group).

(B and C) Data are shown as means ± SD. See also Figure S2.