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. 2020 Aug 27;8:861. doi: 10.3389/fcell.2020.00861

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Copyright © 2020 Sinha, Naash and Al-Ubaidi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Potential routes of flavin transport into and out of the retina and enrichment around photoreceptors. Here we have shown the two potential routes for inflow and outflow of riboflavin through yet to be identified transporters present in both the RPE (outer blood retina barrier) and endothelial cells (inner blood retina barrier). Also shown is the localization of the retinal riboflavin binding protein, retbindin, and its enrichment of bound flavins around the photoreceptor inner segments and RPE-outer segment junction.