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. 2020 Aug 27;8:865. doi: 10.3389/fcell.2020.00865

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Copyright © 2020 Dong, Zhang, Ma, Wang, Lei, Teng, Li, Lin, Feng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Chemical structure of RN486 and cell viability curves in parental and drug-selected or ABCB1-transfected cancer cells administered with RN486. (A) Chemical structure of RN486. (B,C) Concentration-viability curves for KB-3-1, KB-C2, HEK293/pcDNA3.1, and HEK293/ABCB1 cells administered with RN486. Cytotoxicity of RN486 was determined by MTT assay. Dots with error bars in the image represent mean ± SD with three independent assays.