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. 2020 Aug 27;8:865. doi: 10.3389/fcell.2020.00865

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Copyright © 2020 Dong, Zhang, Ma, Wang, Lei, Teng, Li, Lin, Feng and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Administered RN486 resulting in the increase of intracellular [³H]-drug accumulation and the blockade of efflux activity of ABCB1 transporter in ABCB1-overexpressing cancer cells. (A) The effect of RN486 on the accumulation function of [³H]-paclitaxel in ABCB1-mediated MDR cell lines. (B,C) The effects of RN486 on the efflux activity of [³H]-paclitaxel in parental KB-3-1 and its drug-selected KB-C2 cells. Verapamil (3 μM) was a positive control. Results shown as mean ± SD, three independent experiments were performed. *p < 0.05 versus control treatment.