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. 2020 Sep 10;15(8):1533–1544. doi: 10.1007/s11739-020-02485-y

Table 3.

COVID-19 complications

Characteristics Total (n = 128) Deaths caused by SARS-CoV-2 infection (n = 109) Death with SARS-CoV-2 infection (n = 19) p
Days in hospital until death, median (IQR), days 6 (3–10) 7 (3–13) 5 (1–9) 0.035
ARDS 93 (77%) 93 (85%) 0 (0%)  < 0.001
Hyperinflammation 93 (77%) 86 (79%) 7 (37%)  < 0.001
Septic shock 12 (9%) 11 (10%) 1 (5%) 0.505
Pulmonary embolism 3 (2%) 3 (3%) 0 (0%) 0.464
Place of death
 Hospital ward 102 (80%) 83 (76%) 19 (100%)
 Intensive care unit 26 (20%) 26 (24%) 0 (0%) 0.013
Main cause of death
 ARDS or severe lung injury (> 50% lung involvement in X-ray) caused by COVID 104 (81%) 104 (95%) 0 (0%)  < 0.001
 Pulmonary thromboembolism 2 (2%) 2 (2%) 0 (0%)
 Sepsis shock due to COVID 3 (2%) 3 (3%) 0 (0%)
 Sepsis caused by bacterial infection without lung injury 3 (3%) 0 (0%) 3 (16%)
 Wasting associated with age 10 (8%) 0 (0%) 10 (53%)
 Heart failure without acute cardiac injury 2 (2%) 0 (0%) 2 (11%)
 Kidney failure without lung injury or shock 2 (2%) 0 (0%) 2 (11%)
 Bronchoaspiration 1 (1%) 0 (0%) 1 (5%)
 Gastrointestinal bleeding 1 (1%) 0 (9%) 1 (5%)
Week of death
 18–24 March 11 (9%) 7 (6%) 4 (21%) 0.042
 25–31 March 37 (29%) 31 (28%) 6 (32%)
 1–7 April 26 (20%) 22 (20%) 4 (21%)
 8–14 April 21 (16%) 18 (17%) 3 (16%)
 15–21 April 17 (13%) 16 (15%) 1 (5%)
  > 21 April 16 (13%) 15 (14%) 1 (5%)

Bold indicate p values that achieve statistical significance (p < 0.05)

Deaths caused by SARS-CoV-2 infection: patients whose death was caused directly by SARS-CoV-2 infection. Death with SARS-CoV-2 infection: patients where SARS-CoV-2 acted as a precipitating factor to decompensate other chronic or acute pathologies that were the main cause of death

ARDS acute respiratory distress syndrome