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. 2020 Aug 27;14:874. doi: 10.3389/fnins.2020.00874

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Copyright © 2020 Dhanwani, Pham, Premlal, Frazier, Kumar, Pero, Bartolini, Dutra, Marder, Peters, Sulzer, Sette and Lindestam Arlehamn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic profile of PBMC, CD4 memory and CD8 memory T cells in AD and HC (A). PCA analysis of gene expression data from PBMC (HC n = 28 and AD n = 27), CD4 memory (HC n = 28 and AD n = 27), and CD8 memory (HC n = 30 and AD n = 26) T cells of HC and AD (B). Heat map of the top 100 variable genes in PBMC, CD4 memory, and CD8 memory T cells (C). Volcano plots show log₂ fold change vs. –log₁₀ p_adj value for the comparison between AD and HC PBMC, AD, and HC CD4 memory and AD and HC CD8 memory T cells. Dotted lines indicate the cut off limit of log₂ fold change (on x-axis) and –log₁₀ p_adj (on y-axis). Because most of the genes are non-significant, they fall on the axis. The genes with log₂ fold change greater than 0.5 or less than –0.5 and adjusted p-Value less than 0.05 are considered significant and are represented in red.