Figure 6.

IGF-1 mimetic peptide inhibits inflammation and promotes the macrophage M2 transition in vivo. (A) Aortic root cross sections visualized by co-immunofluorescent staining with anti-CCR7 or Arg1 and MOMA2 antibodies with quantitative analysis of MOMA2⁺ CCR7⁺ or MOMA2⁺ Arg1⁺ areas, n=15. (B) Serum TNF-α, IL-β and IL-6 were determined by ELISA, n=8. (C) qRT-PCR analysis of TNF-α and IL-6 in aortas, n=8. Data are presented as mean ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, significantly different from control group.