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. 2020 Aug 27;8:849. doi: 10.3389/fcell.2020.00849

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Copyright © 2020 Rosenkranz, Shaposhnykov, Schnapauff, Epping, Vieira, Heidermann, Schattling, Tsvilovskyy, Liedtke, Meuth, Freichel, Gelderblom and Friese.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TRPV4 inhibition increases transendothelial electrical resistance (TEER) in mouse brain microvascular endothelial cells (MbMECs) under homeostatic conditions. (A) TEER of MbMECs treated with 5 nM of GSK2193874 in comparison to vehicle-treated MbMECs. One representative experiment out of 12 is shown. (B–D) Quantification of TEER of MbMECs treated with 5 nM of GSK2193874 (n = 12) in comparison to vehicle treated MbMECs (n = 12) at 6, 12, and 24 h. TEER was normalized to the time-point of GSK treatment (0 h). Data are presented as box plots. Statistical analysis was performed by two-tailed Student’s t-test. *P < 0.05.