TABLE 3.
Risk factors associated with de novo DR/DQ DSA production.
| Cox proportional hazards regression model (DR, DQ) | ||||
|---|---|---|---|---|
| Variables | Univariate analysis | Multivariate analysis | ||
| HR (95% CI) | p-value | HR (95% CI) | p-value | |
| CSA vs. TAC | 1.314 (0.883–1.977) | 0.179 | ||
| ABO-I vs. ABO-Id/C | 0.613 (0.379–0.954) | 0.0295 | 0.465 (0.283–0.736) | 0.0009 |
| Eplet MM (DRB+DQB) | 1.035 (1.021–1.049)* | <0.0001 | 1.026 (1.009–1.043)* | 0.0028 |
| PIRCHE score | 1.026 (1.013–1.039)** | 0.0001 | 1.016 (1.001–1.032)** | 0.0347 |
| Acute TCMR | 3.052 (1.819–4.880) | <0.0001 | 3.309 (1.937–5.409) | <0.0001 |
*
Hazard ratio for one unit increase is expressed.
**
Hazard ratio for 10 unit increase is expressed.
HR, Hazard ratio; CI, confidence interval; CSA, cyclosporine; TAC, tacrolimus; ABO-I, ABO-incompatible transplantation; ABO-Id/C, ABO-identical/compatible transplantation; MM, mismatch; TCMR, T cell mediated rejection.