Figure 5.

The inhibitory effect of plumbagin on jaw fibrosarcoma tumor growth in PDX model. Patient-derived tumors were subcutaneously established in nude mice. (A,B) When the tumors reached 100–200 mm³ in size, mice were treated with drugs for 3 weeks and a week after drug discontinuation. And representative PDX samples were resected (eight tumors per group) showing the difference in tumor volumes and weights between blank control, plumbagin (2 mg/kg), cisplatin (5mg/kg), and combined group. (C,D) Tumor sizes and weight of mice were measured every 3 days. *p < 0.05, **p < 0.01, and ***p < 0.001.