| Erastin |
System Xc−
|
C30H31ClN4O4
|
BJeLR, HT1080, Calu-1, A-673, Hela, 143B p0 and p+ cell |
NA |
(25,26) |
| Imidazole ketone erastin |
System Xc−
|
C35H35ClN6O5
|
SUDHL-2/5/6/, SUDHL-7/8/9/, SUDHL-10/16, LY-7/9/18,HT-1080, DOHH-2, HBL-1, U2932, A4/FUK, WSU-NHL, Karpas422, A3/KAW, RIVA,U937 |
SUDHL-6 |
(27) |
| Piperazine erastin |
System Xc−
|
C35H41ClN6O4
|
HT-1080, BJeLR, DRD59 |
NA |
(25,28) |
| RSL3 |
GPX4 |
C23H21ClN2O5
|
BJeLR, HT1080, A549, Calu-1, HCT116, MIA PaCa-2, KBM7 |
NA |
(17,29) |
| DPI7 |
GPX4 |
C23H22Cl2N2O3S |
KBM7 |
NA |
(29) |
| FIN56 |
GPX4 |
C25H31N3O5S2
|
BJeLR, HT-1080 |
NA |
(23,30) |
| FINO2 |
GPX4 |
– |
HT-1080 |
NA |
(30) |
| Statins |
GPX4 |
– |
HCC4006, HT-1080 |
LOXIMVI |
(13) |
| Buthionine sulfoximine |
GSH depletion |
C8H18N2O3S |
BJeLR, HCT116/A549 |
NA |
(28,31) |
| Acetaminophen |
GSH depletion |
C8H9NO2
|
HepG2/primary mouse hepatocytes |
NA |
(32) |
| Sulfasalazine |
System Xc− inhibitor |
C18H14N4O5S |
BJeLR, HT1080, Calu-1, DU-145 |
HT-1080, F98 |
(25,31) |
| Sorafenib |
system Xc− inhibition |
C21H16ClF3N4O3
|
HT1080, Calu-1, DU-145, Huh7, ACHN cells |
Huh7, Nude mice |
(31,33-36) |
| Artesunate |
GSH depletion |
C19H28O8
|
PDAC cell lines |
NA |
(35) |
| Lanperisone |
System Xc−
|
C15H18F3NO |
K-rasG12D-transformed MEFs |
Nude mice |
(37) |
| Piperazine erastin |
system Xc−
|
C35H41ClN6O4
|
BJeLR |
Nude mice |
(28) |
| 1 S,3 R-RSL3 |
GPX4 |
C23H21ClN2O5
|
HT-1080, 143B; B16; COHBR1; BT474, PC9 |
BJeLR, HT-1080 |
(14,25,28,38) |
| Cisplatin |
GSH, partially inhibited by DFO, Fer-1, Z-VAD-FMK |
Cl2H6N2Pt |
A549, HCT116 |
NA |
(39) |
| Ferrous ammonium sulfate |
Iron loading |
H8FeN2O8S2
|
IMR-32 |
NA |
(40) |
| Ferric ammonium citrate |
Iron loading |
C12H22FeN3O14
|
HT-1080 |
NA |
(41) |
| Haemin |
Iron loading |
C34H32ClFeN4O4
|
IMR-32, THP-1, THP-1 |
NA |
(41,42) |
| Siramesine+ lapatinib |
Increase the iron level by upregulating TF and down regulating of FPN-1 |
C30H31FN2O, C29H26ClFN4O4S |
MDA MB231, MCF-7, ZR-75, SKBr3 |
NA |
(43) |
| BAY 11-7085 |
Increase in LIP by HMOX1 upregulation |
C13H15NO2S |
MCF-7, MDAMB-468, MDA-MB-231, A549, SKBR3, SKOV3 |
NA |
(44) |
| Bromelain |
Upregulation of ACSL-4 in Kras mutant CRC cells |
– |
CT-116, DLD-1 |
NA |
(45) |
