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. 2020 Aug;9(4):1187–1201. doi: 10.21037/tlcr-19-664

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2020 Translational Lung Cancer Research. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Overall mutation landscape identified by cancer related 295-gene panel. (A) Landscape of somatic mutations identified in the cohort of 511 lung cancer patients. The top bar indicates the mutation number of an individual patient harbors. The side bar presents the total patient number identified with the corresponding mutation. Bottom categories indicate histology subtypes; (B) distribution of mutation frequencies in our cohort compared with TCGA cohort. Different colors indicate different histology sub-groups from our cohort and TCGA population. Asterisk indicates significant different statistically (P value <0.05); (C) pie chart of alterations in driver genes in our LUAD cohort. Mix, adenosquamous carcinoma; LCLC, large-cell neuroendocrine carcinoma; SCLC, small cell lung cancer; LUAD, lung adenocarcinomas.