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. 2020 Aug;9(4):1187–1201. doi: 10.21037/tlcr-19-664

Figure 2.

Figure 2

Mutation relationship analysis in LUAD and LUSC. (A) Heatmap of exclusivity and co-occurrence analysis in LUAD; (B) heatmap of exclusivity and co-occurrence analysis in LUSC; (C) exclusivity and co-occurrence relationship between gene pairs in LUAD; (D) parallel comparison of exclusive and co-occurring genes of EGFR L858R and exon 19 deletion. The OR value of specific gene pair less than 0.5 was defined as mutual exclusivity and OR above 2.0 indicated co-occurrence. P indicates P value, and P value <0.05 was regarded as statistically significant. Different colors in (C) and (D) indicated either mutually exclusivity (red) or con-occurrence (blue) of each gene pair. LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma.