Table 3. Multivariable analysis of PFS and OS for peripheral blood derived parameters.
| Parameter | PFS | OS | |||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | ||
| Monocytes (/μL) | 3.16 | 1.56–6.37 | 0.001 | ||||
| Albumin (mg/dL) | 0.87 | 0.81–0.95 | 0.002 | ||||
| Platelet count (/μL) | 1.00 | 0.99–1.01 | 0.07 | ||||
| Neutrophils (/μL) | 0.86 | 0.73–1.02 | 0.10 | ||||
Only variables that came out more than five times from the ridge regression in the imputed data set were included in this final model. The final model was fitted on the imputed data sets and the results were pooled using Rubin’s rules. Co-variables for ridge regression included PS, histology, stage, gender, age, eosinophils and lymphocytes. PFS, progression-free survival; OS, overall survival, HR, hazard ratio; CI, confidence interval.