Table 2. Comparison of lung-RADS assessment on baseline and subsequent lung cancer screening examinations in the National Lung Screening Trial and the North Carolina Lung Screening Registry by Site Type and Screening Round.
| Lung-RADS | Baseline screening | Subsequent screening | |||||
|---|---|---|---|---|---|---|---|
| NLST* (N=26,455), n (%) | NCLSR academic (N=731), n (%) | NCLSR community (N=2,130), n (%) | NLST* (N=48,671), n (%) | NCLSR academic (N=319), n (%) | NCLSR community (N=857), n (%) | ||
| Lung-RADS assessment | |||||||
| 1 | 14,709 (55.6) | 272 (37.2) | 989 (46.4) | 25,201 (51.8) | 79 (24.8) | 325 (37.9) | |
| 2 | 8,145 (30.8) | 376 (51.4) | 765 (35.9) | 20,606 (42.3) | 203 (63.6) | 423 (49.4) | |
| 3 | 1,697 (6.4) | 45 (6.2) | 204 (9.6) | 588 (1.2) | 13 (4.1) | 63 (7.4) | |
| 3 or 4A | 97 (0.4) | N/A | N/A | 0 | N/A | N/A | |
| 3, 4A, or 4B | 193 (0.7) | N/A | N/A | 0 | N/A | N/A | |
| 4A | 1,107 (4.2) | 22 (3.0) | 111 (5.2) | 851 (1.7) | 14 (4.4) | 23 (2.7) | |
| 4A or 4B | 0 | N/A | N/A | 280 (0.6) | N/A | N/A | |
| 4B | 358 (1.4) | 10 (1.4) | 55 (2.6) | 896 (1.8) | 8 (2.5) | 20 (2.3) | |
| 4X | 149 (0.6) | 6 (0.8) | 6 (0.3) | 249 (0.5) | 2 (0.6) | 3 (0.4) | |
| Lung-RADS categorized | |||||||
| Negative | 22,854 (86.4) | 648 (88.6) | 1,754 (82.3) | 45,807 (94.1) | 282 (88.4) | 748 (87.3) | |
| Positive | 3,601 (13.6) | 83 (11.4) | 376 (17.7) | 2,864 (5.9) | 37 (11.6) | 109 (12.7) | |
* REF: Pinsky PF et al. Ann Intern Med 2015.