Table S9. The top 10 most relevant features (including clinical factors) for the detection of exon-21 L858R mutation (Model Exon21_B).

Feature	AUC	MI	R2	P
logarithm_glcm_InverseVariance	0.675	0.061	0.097	4.09E-06
original_firstorder_Skewness	0.654	0.06	0.068	1.33E-04
wavelet-HLL_firstorder_Median	0.666	0.033	0.045	2.02E-03
original_glszm_SizeZoneNonUniformityNormalized	0.614	0.032	0.040	3.34E-03
logarithm_ngtdm_Contrast	0.616	0.086	0.040	3.74E-03
wavelet-HHH_firstorder_Mean	0.601	0.063	0.036	5.71E-03
wavelet-LHL_glcm_ClusterShade	0.597	0.041	0.029	1.38E-02
wavelet-HHH_glszm_GrayLevelVariance	0.591	0.052	0.025	2.10E-02
custom_PatientSex	0.579	0.017	0.023	2.63E-02
wavelet-LLL_glszm_ZoneVariance	0.570	0.058	0.020	3.84E-02

AUC, area under the receiver operating characteristic curve; MI, mutual information, represents redundancy; P value is the significance of the minimum redundancy maximum relevance (mRMR).