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. 2020 Sep 9;10:14838. doi: 10.1038/s41598-020-71653-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Quantitative proteomics shows altered cellular content and bacterial response to LA in T7SS mutants. S. aureus USA300 WT and mutants (ΔessC and ΔesxC) were grown in TSB or TSB supplemented with LA. (A) Venn diagram showing the number of proteins with altered abundance compared to WT specific to ΔessC (23) or ΔesxC (10), and common to ΔessC and ΔesxC (14). (B) The 14 proteins that are similarly changed in ΔessC and ΔesxC mutants are highlighted on a volcano plot. (C) Volcano plot showing the extensive change in the LA-treated WT compared to WT. (D) Venn diagram displaying the numbers of proteins with altered relative abundance upon LA challenge of WT (LA.WT), ΔessC (LA.dEssC) or ΔesxC (LA.dEsxC) compared to the respective untreated samples.