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. 2020 Sep 9;10:14838. doi: 10.1038/s41598-020-71653-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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An altered oxidoreductive response in T7SS mutants in response to LA. Heatmaps depicting the P values of enriched (A) or diminished (B) molecular functions following a gene set analysis based on GO (gene ontology) annotations. Molecular functions that are changed in at least one strain (P < 0.05) following growth in presence of LA are shown. The shades of blue (A) or red (B) correspond to – log₁₀ (P value). ROS levels were measured in cultures of S. aureus USA300 JE2 WT, ΔessC or ΔesxC grown to OD₆₀₀ of 1.0 treated (C) with or without LA (D) using DCF reagent. Means ± SD are shown N = 5. *Indicates P < 0.05, **indicates P < 0.01, ***indicates P < 0.001 using the Kruskal–Wallis rank test.