Table 1.
Proteins with changed abundance in ΔessC and ΔesxC mutants relative to the WT USA300 JE2.
| Functions | Uniprot ID | ΔessC/WT | ΔesxC/WT | Description | ||
|---|---|---|---|---|---|---|
| Log2 FC | Adjusted P value | Log2 FC | Adjusted P value | |||
| Signal transduction systems | Q2FK09 | − 3.0 | 4.90E−13 | − 3.1 | 4.90E−13 | Sensory transduction protein LytR |
| Q2FH23 | − 2.9 | 0.002527 | − 2.1 | 0.026184 | Response regulator ArlR | |
| Membrane proteins | A0A0H2XF42 | 3.0 | 1.75E−10 | 0 | 1 | Cytochrome D ubiquinol oxidase, subunit I |
| A0A0H2XDZ5 | 1.7 | 1.68E−05 | 0 | 1 | Uncharacterized membrane protein | |
| A0A0H2XFJ8 | 2.0 | 0.001077 | 0.5 | 0.883953 | Uracil permease | |
| A0A0H2XGW7 | 2.7 | 0.005757 | 2.5 | 0.010784 | Putative lipoprotein | |
| A0A0H2XIA9 | 1.0 | 0.006115 | 0 | 1 | Protein translocase subunit SecY | |
| Q2FIN2 | 1.6 | 0.029451 | 0.5 | 0.970614 | Prolipoprotein diacylglyceryl transferase LGT | |
| A0A0H2XKD9 | 2.0 | 0.038093 | 1.8 | 0.070347 | Staphylococcal respiratory response protein SrrB | |
| A0A0H2XFE1 | 3.4 | 0.039814 | 1.1 | 0.970614 | Peptidase | |
| A0A0H2XJV8 | 2.0 | 0.04444 | 1.5 | 0.231285 | Cyclic-di-AMP phosphodiesterase | |
| A0A0H2XGF4 | 3.0 | 0.044681 | 0.9 | 0.986458 | Sodium:dicarboxylate symporter family protein | |
| A0A0H2XHV2 | 2.5 | 0.049168 | 2.4 | 0.070182 | Glycine betaine transporter OpuD | |
| Stress response | A0A0H2XKH6 | 2.2 | 5.80E−05 | 2.5 | 1.07E−05 | Universal stress protein family |
| A0A0H2XIZ0 | 0.0 | 1 | − 3.4 | 1. 06E−10 | OsmC/Ohr family protein | |
| DNA repair | Q2FHE2 | − 2.3 | 1.79E−08 | − 2.3 | 1.19E-08 | DNA mismatch repair protein MutL |
| A0A0H2XI63 | − 2.0 | 0.004036 | − 2.0 | 0.004036 | DNA repair protein RadA | |
| A0A0H2XHT1 | − 0.3 | 0.708343 | − 1.9 | 0.008379 | Formamidopyrimidine-DNA glycosylase MutM | |
| Oxidation–reduction process | A0A0H2XJ90 | 1.1 | 0.038093 | 1.0 | 0.088334 | D-isomer specific 2-hydroxyacid dehydrogenase family protein |
| A0A0H2XHE0 | 2.4 | 0.039099 | − 0.1 | 1 | Thiol-disulphide oxidoreductase, DCC family protein | |
| A0A0H2XGR9 | 0.0 | 1 | 1.4 | 8.89E-08 | Oxidoreductase, Gfo/Idh/MocA family | |
| A0A0H2XK08 | 1.0 | 0.406975 | 2.9 | 0.00791 | Oxidoreductase, short chain dehydrogenase/reductase family | |
| A0A0H2XFZ3 | − 0.8 | 0.404225 | 2.1 | 0.016405 | Nitroreductase family protein | |
| Hydrolases | A0A0H2XE49 | 2.9 | 1.07E−06 | 2.9 | 5.99E−07 | Amidohydrolase |
| Q2FES9 | − 2.7 | 0.003385 | − 0.3 | 1 | Uncharacterized hydrolase | |
| A0A0H2XFF2 | − 0.8 | 0.016697 | − 0.5 | 0.157809 | Peptidase, U32 family | |
| A0A0H2XJH8 | 0.0 | 1 | 2.8 | 1.06E−10 | Peptidase M20 domain-containing protein 2 | |
| A0A0H2XJ54 | 0.0 | 1 | 2.0 | 0.000949 | Hydrolase (HAD superfamily) | |
| Q2FEG2 | − 0.2 | 0.854748 | − 2.9 | 0.004615 | Formimidoylglutamase | |
| Metabolism | A0A0H2XGU2 | − 1.6 | 4.99E−06 | − 0.1 | 1 | Pseudouridine synthase |
| A0A0H2XK15 | 2.8 | 0.004424 | 0.9 | 0.777138 | 1-phosphatidylinositol phosphodiesterase | |
| Q2FEK2 | − 1.6 | 0.038093 | − 0.3 | 1 | Urease accessory protein UreE | |
| Q2FI05 | 1.1 | 0.038093 | 0.0 | 1 | Bifunctional purine biosynthesis protein PurH | |
| Q2FIL2 | 2.9 | 0.038093 | 0.8 | 0.970614 | SsrA-binding protein | |
| A0A0H2XII6 | 1.8 | 0.038093 | 1.5 | 0.088334 | Orn/Lys/Arg decarboxylase | |
| A0A0H2XJR8 | − 0.9 | 0.04444 | − 0.5 | 0.61246 | RNA methyltransferase, RsmD family | |
| A0A0H2XKG7 | 0.0 | 1 | 1.4 | 8.18E−08 | Aspartokinase | |
| Cell wall composition | A0A0H2XJQ4 | − 4.0 | 4.92E−11 | − 4.0 | 3.28E−11 | Acetyltransferase, GNAT family |
| A0A0H2XKG3 | − 2.3 | 0.001238 | − 1.7 | 0.016405 | Fibronectin binding protein B | |
| A0A0H2XJC8 | − 2.3 | 0.009779 | − 3.0 | 0.000819 | Phi77 ORF017-like protein (Toxin MazF) | |
| Q2FE03 | 0.0 | 1 | 2.6 | 1.18E−12 | Fibronectin-binding protein A | |
| Nucleotide binding | A0A0H2XHY5 | − 2.3 | 8.58E−06 | − 2.3 | 6.01E−06 | ATP-grasp domain protein |
| A0A0H2XFA5 | 3.3 | 0.014259 | 3.5 | 0.008379 | Putative GTP-binding YqeH protein | |
| Uncharacterised proteins | A0A0H2XGJ8 | 2.2 | 0.000372 | 2.4 | 9.41E−05 | Uncharacterized protein |
| A0A0H2XE09 | 2.1 | 0.008231 | 1.9 | 0.016405 | Ybbr-like uncharacterized protein | |
| Q2FFI4 | 3.4 | 0.020136 | 0.9 | 0.970614 | UPF0316 membrane protein | |
| A0A0H2XG24 | 1.1 | 0.022345 | 0.8 | 0.088334 | Uncharacterized protein | |