Table 3.
Comparison of patients with elevated and normal AST–ALT values.
| Variables | AST–ALT ≤ 40 (n = 401) mean ± sd | AST–ALT > 40 (n = 153) mean ± sd | p |
|---|---|---|---|
| AST (IU/L) | 23.86 ± 7.15 | 68.55 ± 50.15 | 0.001 |
| ALT (IU/L) | 19.87 ± 8.40 | 71.08 ± 82.23 | 0.001 |
| ALP (IU/L) | 74.67 ± 34.57 | 89.57 ± 68.45 | 0.066 |
| GGT (IU/L) | 34.66 ± 42.09 | 76.61 ± 84.57 | 0.001 |
| LDH (IU/L) | 251.96 ± 84.17 | 363.96 ± 187.93 | 0.001 |
| Albumin (g/dl) | 3.98 ± 0.52 | 3.85 ± 0.54 | 0.007 |
| CRP (mg/L) | 56.52 ± 58.86 | 91.24 ± 87.72 | 0.001 |
| Procalsitonin (ng/ml) | 0.22 ± 0.89 | 1.46 ± 6.80 | 0.001 |
| Ferritin (mg/dl) | 448.46 ± 713.24 | 1365.25 ± 6931.00 | 0.001 |
| d-Dimer (μg/L) | 1260.10 ± 1992.92 | 1936.48 ± 2854.12 | 0.001 |
| Fibrinogen (mg/dl) | 521.54 ± 131.28 | 557.58 ± 155.33 | 0.003 |
| aPTT (s) | 29.54 ± 4.96 | 29.96 ± 5.08 | 0.260 |
| Lymp (108 cell/μl) | 1.26 ± 0.65 | 1.13 ± 0.56 | 0.015 |
| Wbc(108 cell/μl) | 7.08 ± 3.50 | 7.24 ± 3.19 | 0.378 |
| Lactate (mmol/L) | 1.73 ± 1.33 | 2.16 ± 1.74 | 0.005 |
| Hgb (g/dl) | 12.84 ± 1.93 | 13.37 ± 1.69 | 0.006 |
| Total bilirubin (mg/dl) | 0.41 ± 0.22 | 0.84 ± 1.05 | 0.001 |
| Direct bilirubin (mg/dl) | 0.22 ± 0.27 | 0.28 ± 0.35 | 0.001 |
| Age | 57.01 ± 15,58 | 56.41 ± 16.48 | 0.237 |
| BMI | 29,20 ± 4,71 | 29,88 ± 4,67 | 0,349 |
| Hospitalization days | 8,87 ± 5,92 | 10,76 ± 8,39 | 0.048 |
aPTT(s): active partial thromboplastin time.
BMI: body mass index.
p value was obtained using the Mann–Whitney U test. Statistical significance level is defined as p < 0.05.
In patients with AST/ALT > 40 on admission; we detected higher levels of procalcitonin, C-reactive protein, ferritin, fibrinogen, d-dimer, lactate and total bilirubin, which were statistically significant. In addition, the period of hospital stay was longer in this group of patients (p = 0.048). Albumin and lymphocyte values were statistically significantly lower in these patients. The age distribution of both groups was not significantly different.