Table 9.
Classification by prognosis.
| Good Prognosis |
Poor Prognosis |
p | ||||
|---|---|---|---|---|---|---|
| n (439) | (79.2)% | n (115) | (20.8)% | |||
| According to R value | Normal | 293 | 84.4 | 54 | 15.6 | 0.001 |
| Cholestatic injury | 100 | 73.5 | 36 | 26.5 | ||
| Mixed injury Pattern | 39 | 63.9 | 22 | 36.1 | ||
| Hepato-cellular Injury | 7 | 70.0 | 3 | 30.0 | ||
| Cholestatic enzyme height (value) | Yes | 10 | 47.6 | 11 | 52.4 | 0.001 |
| No | 429 | 80.5 | 104 | 19.5 | ||
| AST–ALT | Normal | 338 | 84.3 | 63 | 15.7 | 0.001 |
| Minimal | 74 | 66.1 | 38 | 33.9 | ||
| Mild | 25 | 71.4 | 10 | 28.6 | ||
| Acute hepatitis Attack | 2 | 33.3 | 4 | 66.7 | ||
p value was obtained using the Mann–Whitney U test. Statistical significance level is defined as p < 0.05.
Subjects were classified into two groups based on their prognosis. The prognosis of subjects was evaluated using the R ratio (R ratio <2, 2–5 and >5) which refers to cholestatic injury, mixed injury pattern and hepatocellular injury, respectively. The best prognosis was seen in the group with a normal R value (84.4%), and the worst prognosis was seen in the mixed-injury pattern group (36.1%).
Patients with ALP > 1.5 × ULN and/or GGT > 3 × ULN were considered as the elevated cholestatic liver enzyme group that had a poor prognosis rate of 52.4%. On the other hand, the poor prognosis rate was 19.5% in the normal cholestatic liver enzyme group (p 0.001).
Patients were divided into 3 groups according to liver transaminase elevation rates: minimal (n = 112 patients), mild (n = 35 patients) and severe (acute hepatitis) (n = 6 patients), defined as liver transaminase elevations <2 times ULN, <5 times ULN, >5 times ULN, respectively. The best prognosis was seen in the group with normal ALT–AST levels.