Table 2.
Characteristics of Excluded Studies.
| Study | Title | Journal | Study Design | # Subjects | Block Depth | Special Population | Sugammadex Dose | Neostigmine Dose | Comments |
|---|---|---|---|---|---|---|---|---|---|
| Amorin, 2014 | Neostigmine vs. sugammadex: observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale | Acta Anaesthesiol Scand 2014; 58:1101–1110 | Single center convenience sample | 101 | Various | No | na | na | Block not standardized |
| Balaka, 2011 | Comparison of sugammadex to neostigmine reversal of neuromuscular blockade in patients with myasthenia gravis | J Cardiothorac Vasc Anes 2011; 25:S22-S23 | Single center randomized trial | 40 | Shallow | Yes, myasthenia gravis | 4 mg/kg | 2.5 mg | Insufficient data |
| Boon, 2016 | Improved postoperative oxygenation after antagonism of moderate neuromuscular block with sugammadex versus neostigmine after extubation in 'blinded' conditions. | Br J Anaesth. 2016; 117:410–1 | Multicenter double blind trial | 100 | Moderate | No | 2 mg/kg | 2.5 mg | No outcomes of interest |
| Flockton, 2008 | Reversal of rocuronium-induced neuromuscular block with sugammadex is faster than reversal of cisatracurium-induced block with neostigmine | Br J Anaesth 2008; 100:622–30 | Single center randomized trial | 73 | Moderate | No | 2 mg/kg | 50 mcg/kg | Rocuronium not compared in both groups |
| Geldner, 2012 | a randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery | Anesthesia 2012; 67:991–998 | Multicenter randomized trial | 140 | Various | No | 4 mg/kg | 50 mcg/kg | Block not standardized |
| Hakimoglu, 2016 | Comparison of sugammadex and neostigmine-atropine on intraocular pressure and postoperative effects | Kaohsiung J Med Sci 2016; 32:80–5 | Single center randomized trial | 60 | Moderate | No | 4 mg/kg | 50 mcg/kg | No outcomes of interest |
| Kizilay, 2016 | Comparison of neostigmine and sugammadex for hemodynamic parameters in cardiac patients undergoing noncardiac surgery | J Clin Anesth 2016; 28:30–5 | Single center randomized trial | 90 | Moderate | No | 3 mg/kg | 30 mcg/kg | No outcomes of interest |
| Ledowski, 2014 | Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade Sugammadex, neostigmine or no reversal. | Eur J Anaesthesiol 2014; 31:423–29 | Single center retrospective cohort study | 1444 | Various | No | Various | Various | Block not standardized |
| Martinez-Ubieto, 2016 | Prospective study of residual neuromuscular block and postoperative respiratory complications in patients reversed with neostigmine versus sugammadex | Minerva Anestesiol 2016; 82:735–42 | Single center prospective cohort study | 325 | Various | No | Various | Various | Insufficient data |
| Nemes, 2017 | Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring. A partially randomised placebo controlled trial | Eur J Anaesthesiol 2017; 34:609–616 | Partially randomized placebo-controlled trial | 125 | na | No | 2 mg/kg | 60 mcgkg | Block not standardized |
| Oh, 2019 [7] | Retrospective analysis of 30-day unplanned readmission after major abdominal surgery with reversal by sugammadex or neostigmine | Br J Anaesth 2019; 122:370–378 | Single center retrospective cohort study | 1479 | na | No | > 2 mg/kg | 30 – 50 mcg/kg | No outcomes of interest |
| Olesnicky, 2016 | The effect of routine availability of sugammadex on postoperative respiratory complications: a historical cohort study | Minerva Anestesiol 2017; 83:248-254 | Single center retrospective pre-post study | 922 | Various | No | Various | Various | No comparison with neostigmine or placebo |
| Raziel, 2013 | Comparison of two neuromuscular anesthesics reversal in obese patients undergoing bariatric surgery - A prospective study | Conference Paper in Obesity Surgery, Vienna, Austria. August 2013 | Single center randomized trial | 40 | na | Yes, obesity | na | na | Insufficient data |
| Sauer, 2011 | The influence of residual neuromuscular block on the incidence of critical respiratory events. A randomised, prospective, placebo-controlled trial | Eur J Anaesthesiol 2011; 28:842–848 | Single center randomized trial | 132 | Deep | No | na | 20 mcg/kg vs. placebo | No outcomes of interest |
| Sherman, 2014 | The effect of sugammadex vs. neostigmine on the postoperative respiratory complications following laparoscopic sleeve gastrectomy | Eur J Anaesthesiol 2014; Abstract 9AP4–5 | Single center randomized trial | 57 | Various | Yes, obesity | 2 mg/kg | 2.5 mg | No outcomes of interest |
| Stourac, 2016 | Low-dose or high-dose rocuronium reversed with neostigmine or sugammadex for cesarean delivery anesthesia: a randomized controlled noninferiority trial of time to tracheal intubation and extubation | Anesth Analg 2016; 122:1536–45 | Two center randomized trial | 240 | Various | Yes, parturients | 2 – 4 mg/kg | 30 mcg/kg | Block not comparable in both groups |
| Watts, 2012 | The influence of unrestricted use of sugammadex on clinical anesthetic practice in a tertiary teaching hospital | Anaesth Intensive Care 2012; 40: 333–339 | Single center retrospective case audit | 374 | Various | No | Various | Various | No comparison with neostigmine or placebo |