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. 2020 Sep 1;2020:3035624. doi: 10.1155/2020/3035624

Figure 5.

Figure 5

miR-6734-5p exacerbates lncRNA OTUD6B-AS1-induced oxidative damage. (a–d) ROS, MDA, SOD, and GSH-Px production in bladder cancer cells following lncRNA OTUD6B-AS1 overexpression or transfection with mimics. (e–g) Nrf2 expression in cytoplasm and nucleus following lncRNA OTUD6B-AS1 overexpression or transfection with mimics. (h) Apoptosis determined by flow cytometry following lncRNA OTUD6B-AS1 overexpression or transfection of mimics. (i) Statistical analysis of flow cytometry apoptosis data. (j) Apoptosis was determined by TUNEL staining following lncRNA OTUD6B-AS1 overexpression or transfection of mimics. (k) Statistical analysis of cells positive for TUNEL staining. (l) Cell viability was determined by CCK-8 assay following lncRNA OTUD6B-AS1 overexpression or transfection of mimics. ∗P < 0.05, ∗∗P < 0.01 vs. control cells; #P < 0.05, ##P < 0.01 vs. cells overexpressing lncRNA OTUD6B-AS1; &P < 0.05, &&P < 0.01 vs. cells transfected with mimics.