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. 2020 Apr 6;33(9):804–812. doi: 10.1093/ajh/hpaa058

Figure 1.

Figure 1.

Impaired mitophagic degradation of damaged mitochondria leads to oxidative stress. In endothelial cells this prooxidative milieu promotes the release of contractile factors, quenches nitric oxide bioavailability, and uncouples endothelial nitric oxide synthase (eNOS). Abbreviation: ROS, reactive oxygen species.