Table 2.
The optimal prognostic signature.
| Symbol | Module | Expression | Type | Univariate Cox regression | Multivariate Cox regression | LASSO coefficient | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||||
| GINS2 | Green | Upregulated | mRNA | 3.248 | 1.344-7.849 | 4.450E-03 | 1.399 | 1.261-2.036 | 3.33E-02 | 1.4561 |
| NLGN2 | Yellow | Downregulated | mRNA | 6.514 | 1.237-14.31 | 1.350E-02 | 3.012 | 2.000-9.079 | 2.10E-02 | 1.7956 |
| EBNA1BP2 | Blue | Upregulated | mRNA | 7.112 | 1.048-18.28 | 2.250E-02 | 4.470 | 2.904-12.115 | 2.79E-02 | 2.7422 |
| DLG5-AS1 | Blue | Downregulated | lncRNA | 0.629 | 0.199-0.987 | 3.655E-02 | 0.589 | 0.290-0.931 | 4.59E-02 | -0.2216 |
| MAGI2-AS3 | Yellow | Downregulated | lncRNA | 0.354 | 0.0572-0.914 | 2.210E-02 | 0.512 | 0.220-0.913 | 4.51E-02 | -0.7093 |
| RHPN1-AS1 | Green | Upregulated | lncRNA | 0.272 | 0.0286-0.581 | 2.210E-02 | 0.513 | 0.236-0.711 | 3.89E-02 | -1.5300 |
| MELK | Green | Upregulated | mRNA | 0.557 | 0.047-0.625 | 1.950E-02 | 0.360 | 0.110-1.179 | 3.84E-02 | -0.0482 |
| EIF5AL1 | Blue | Upregulated | mRNA | 0.194 | 0.0311-0.414 | 4.000E-02 | 0.540 | 0.273-0.701 | 3.26E-02 | -1.5588 |
| G6PC3 | Blue | Upregulated | mRNA | 0.237 | 0.0617-0.912 | 1.800E-02 | 0.352 | 0.1117-0.509 | 2.66E-02 | -1.5551 |
HR: hazard ratio; CI: confidence interval; LASSO: least absolute shrinkage and selection operator.