Table 3.
The univariate and multivariate Cox regression analysis to identify independent prognostic factors.
| Variables | TCGA (n = 494) | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | ||
| Age (years, mean ± SD) | 61.03 ± 6.84 | 1.053 | 0.956-1.160 | 2.91E-01 | — | — | — |
| Pathologic_M (M0/M1/-) | 452/3/39 | 2.892 | 0.470-5.366 | 1.48E-01 | — | — | — |
| Pathologic_N (N0/N1/-) | 344/78/72 | 3.609 | 0.799-16.30 | 7.46E-02 | — | — | — |
| Pathologic_T (T2/T3/T4/-) | 186/291/10/7 | 2.242 | 0.601-8.373 | 2.27E-01 | — | — | — |
| Radiation therapy (yes/no/-) | 59/386/49 | 2.984 | 0.577-15.42 | 2.33E-01 | — | — | — |
| Targeted molecular therapy (yes/no/-) | 52/392/50 | 3.127 | 0.592-16.52 | 2.20E-01 | — | — | — |
| Gleason score (6/7/8/9/10) | 45/245/63/137/4 | 2.959 | 1.337-6.549 | 2.28E-03 | 1.685 | 1.163-3.963 | 2.32E-02 |
| Prostate-specific antigen | 1.75 ± 15.89 | 1.062 | 1.004-1.124 | 9.60E-05 | 1.022 | 1.019-1.054 | 1.52E-02 |
| Recurrence (yes/no/-) | 368/58/68 | 7.224 | 1.937-26.94 | 5.68E-04 | 2.081 | 0.424-10.222 | 3.67E-01 |
| Prognostic score status (high/low) | 247/247 | 9.574 | 1.212-17.56 | 5.06E-03 | 5.846 | 1.708-18.27 | 1.01E-02 |
| Death (dead/alive) | 10/484 | — | — | — | — | — | — |
| Overall survival days (months, mean ± SD) | 36.10 ± 26.32 | — | — | — | — | — | — |
SD: standard deviation; TCGA: The Cancer Genome Atlas; HR: hazard ratio; CI: confidence interval. Bold indicated the factors with statistical significance.