Table 2.

The HR of APOE Genotype From Cox Proportional Hazards Model

	AD Cohort (N = 11 871)				MCI Cohort (N = 8305)
	Unadjusted Model		Adjusted Modela		Unadjusted Model		Adjusted Modela
Variable	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value	HR (95% CI)	P Value
ε3ε3 (Reference group)
ε3ε4	2.11 (1.9–2.33)	<.0001	2.1 (1.89–2.33)	<.0001	1.24 (1.11–1.37)	<.0001	1.41 (1.27–1.57)	<.0001
ε2ε3	0.78 (0.65–0.95)	.013	0.82 (0.67–0.99)	.041	0.95 (0.82–1.11)	.511	0.9 (0.77–1.05)	.181
ε4ε4	3.88 (3.3–4.55)	<.0001	3.57 (3.03–4.22)	<.0001	1.8 (1.43–2.25)	<.0001	2.53 (2.01–3.18)	<.0001
ε2ε4	1.64 (1.24–2.16)	<.0001	1.74 (1.32–2.3)	<.0001	1.35 (1.03–1.77)	.032	1.52 (1.15–1.99)	.003
ε2ε2	0.47 (0.15–1.45)	.186	0.45 (0.14–1.39)	.164	1.29 (0.71–2.33)	.403	1.19 (0.65–2.15)	.576
ε2ε4 comparing to other genotype as reference group
ε2ε4 vs ε3ε4	0.78 (0.59–1.02)	.074	0.83 (0.63–1.09)	.187	1.09 (0.83–1.44)	.547	1.07 (0.81–1.42)	.620
ε2ε4 vs ε4ε4	0.42 (0.31–0.57)	<.0001	0.49 (0.36–0.66)	<.0001	0.75 (0.53–1.06)	.100	0.60 (0.42–0.84)	.003
ε2ε4 vs ε2ε3	2.09 (1.52–2.88)	<.0001	2.13 (1.54–2.94)	<.0001	1.42 (1.05–1.91)	.022	1.68 (1.25–2.27)	.001
ε2ε4 vs ε2ε2	3.52 (1.10–11.3)	.034	3.90 (1.22–12.5)	.022	1.05 (0.55–2.00)	.894	1.28 (0.67–2.44)	.457

Note: AD, Alzheimer’s disease; HR, hazard ratio; MCI, mild cognitive impairment.

^aModels were adjusted for age, sex, education, baseline cognitive status, and year of initial visit.