Table 1.
Demographic and Clinicopathologic Characteristics of Acute Myeloid Leukemia Patients in The Cancer Genome Atlas Cohort
| Variables | Total, N = 112 | Low risk (n = 56) | High risk (n = 56) | p |
|---|---|---|---|---|
| Age, years | ||||
| ≤60 | 44 | 16 (36.4%) | 28 (64.6%) | 0.032 |
| >60 | 68 | 40 (58.8) | 28 (41.2%) | |
| Sex | ||||
| Female | 55 | 29 (52.7%) | 26 (47.3%) | 0.23 |
| Male | 57 | 27 (47.3%) | 30 (52.6%) | |
| FAB category | ||||
| M0 | 11 | 7 (63.6%) | 4 (36.3%) | <0.001 |
| M1 | 26 | 11 (42.3%) | 15 (57.6) | |
| M2 | 26 | 17 (65.3) | 9 (34.6%) | |
| M3 | 13 | 13 (100%) | 0 | |
| M4 | 23 | 7 (30.4%) | 16 (69.6%) | |
| M5 | 10 | 0 | 10 (100%) | |
| M6 | 1 | 0 | 1 (100%) | |
| M7 | 1 | 1 (100%) | 0 | |
| Risk group | ||||
| Favorable | 27 | 22 (81.4%) | 5 (18.6%) | <0.001 |
| Intermediate/normal | 60 | 26 (43.3%) | 34 (56.7%) | |
| Poor | 24 | 7 (29.2%) | 17 (70.8%) | |
| Hydroxyurea administration | ||||
| Yes | 28 | 9 (32.1%) | 19 (67.8%) | 0.015 |
| No | 84 | 47 (55.9%) | 37 (44.1%) | |
| FLT3 status | ||||
| Mutated | 30 | 15 (50%) | 15 (50%) | 0.14 |
| Wild type | 82 | 41 (50%) | 41 (50%) | |
| NPM1 status | ||||
| Mutated | 28 | 10 (35.7%) | 18 (64.3%) | 0.57 |
| Wild type | 84 | 46 (54.8%) | 38 (45.2%) | |