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. 2020 Sep 8;30(9):1338–1345. doi: 10.1089/thy.2019.0711

FIG. 1.

FIG. 1.

Mice immunized with adenovirus containing hTG develop T cell proliferative responses to hTG and TG2098. (A) Average proliferation indexes of T cells to stimulation with TG and TG2098 from mice immunized with control Ad-LacZ. (B) Average proliferation indexes of T cells to stimulation with TG and TG2098 from mice immunized with Ad-TG. (C) Average proliferation indexes of T cells to stimulation with TG and TG2098 from mice induced with classical EAT. Stimulation with scrambled APO was used as NC, and stimulation with CD3/CD28 beads was used as a positive control. Proliferation index ≥1.5 was considered as a positive response to the stimulant. The pound sign (#) indicates stimulation index ≥1.5. The data are shown as means ± SE. Statistical analysis was performed by using two-way ANOVA followed by Bonferroni's multiple-comparison test or unpaired t-test. *p < 0.05, **p < 0.01 ***p < 0.001 versus medium (Ad-LacZ, n = 13; Ad-TG, n = 17; EAT, n = 7). ANOVA, analysis of variance; APO, apopeptide; EAT, experimental autoimmune thyroiditis; hTG, human TG; NC, negative control; SE, standard error; TG, thyroglobulin.