Table 3.
Adjusted Odds Ratios for the Association of Insulin Resistance and Measures of Alcohol Use
AUDIT-C |
Phosphatidylethanol |
Lifetime drinking history (g) |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Any |
1–3 (1–2 F) |
4–5 (3–5 F) |
6–7 |
8–12 |
Positive (>8 ng/mL) |
Misuse (>250 ng/mL) |
>600,00 |
27,907–171,360 |
171,361–471,975 |
480,297–2,056,320 |
|
Reference AUDIT-C = 0 | Reference PEth = 0 | Reference LDH <27,906 | |||||||||
Metabolic syndrome | 0.76 (0.38, 1.55) | 0.94 (0.42, 2.12) | 0.56 (0.24, 1.38) | 0.43 (0.16, 1.19) | 1.33 (0.55, 3.24) | 0.56 (0.33, 0.95) | 1.02 (0.53, 1.97) | 1.71 (0.89, 3.30) | 1.46 (0.68, 3.14) | 2.58 (1.20, 5.51) | 2.43 (1.09, 5.00) |
Men | 0.78 (0.29, 2.08) | 0.94 (0.28, 2.56) | 0.61 (0.19, 1.94) | 0.79 (0.20, 2.41) | 1.05 (0.33, 3.34) | 0.57 (0.29, 1.14) | 1.28 (0.58, 2.8) | 0.90 (0.39, 2.07) | 1.36 (0.46, 4.03) | 3.03 (1.06, 8.68) | 1.95 (0.68, 5.58) |
Women | 1.12 (0.36, 3.47) | 2.5 (0.6, 10.4) | 0.87 (0.22, 3.4) | 4.3 (0.75, 24.7) | 0.58 (0.24, 1.42) | 0.73 (0.15 3.52) | 4.68 (1.36, 23.6) | 1.76 (0.55, 5.64) | 1.16 (0.32, 4.2) | 2.11 (0.56, 7.96) | |
HOMA-IR | 0.60 (0.30, 1.19) | 0.80 (0.36, 1.78) | 0.49 (0.22, 1.09) | 0.71 (0.29, 1.72) | 0.46 (0.2, 1.07) | 0.8 (0.48, 1.32) | 0.64 (0.35, 1.18) | 0.96 (0.52, 1.78) | 0.90 (0.46, 1.79) | 1.03 (0.53, 2.03) | 1.05 (0.53, 2.03) |
Men | 0.53 (0.20, 1.39) | 0.94 (0.32, 2.79) | 0.59 (0.18, 1.91) | 0.40 (0.13, 1.25) | 0.4 (0.13, 1.25) | 0.84 (0.43, 1.63) | 0.83 (0.40, 1.70) | 0.81 (0.37, 1.76) | 0.91 (0.36, 2.25) | 0.90 (0.36, 2.22) | 0.83 (0.33, 2.05) |
Women | 0.80 (0.24, 2.65) | 0.47 (0.11, 2.05) | 0.89 (0.22 3.55) | 1.73 (0.28, 10.64) | 0.78 (0.15, 4.16) | 0.90 (0.36, 2.24) | 0.55 (0.11, 2.83) | 0.71 (0.2, 2.55) | 1.08 (0.31, 3.74) | 1.22 (0.34, 4.41) | 0.9 (0.25, 3.23) |
Triglyceride index | 0.98 (0.51, 1.88) | 1.07 (0.51, 2.24) | 0.84 (0.40, 1.76) | 1.07 (0.46, 2.5) | 1.02 (0.46, 2.27) | 0.98 (0.60, 1.60) | 1.1 (0.62, 1.94) | 1.16 (0.64, 2.12) | 1.15 (0.61, 2.18) | 1.32 (0.69, 2.53) | 1.44 (0.75, 2.78) |
Men | 0.54 (0.21, 1.36) | 0.53 (0.19, 1.47) | 0.48 (0.17, 1.41) | 0.71 (0.23, 2.16) | 0.49 (0.17, 1.42) | 0.96 (0.51, 1.78) | 1.06 (0.55, 2.04) | 0.94 (0.46, 1.94) | 1.10 (0.48, 2.55) | 1.39 (0.60, 3.23) | 1.39 (0.59, 3.26) |
Women | 2.14 (0.69, 6.63) | 2.74 (0.72, 10.5) | 1.9 (0.54, 7.04) | 1.02 (0.17, 5.83) | 3.39 (0.69, 16.6) | 0.94 (0.40, 2.20) | 1.08 (0.25, 4.71) | 1.62 (0.46, 5.7) | 1.28 (0.44, 3.7) | 0.94 (0.28, 3.13) | 1.09 (0.32, 3.71) |
McAuley index | 0.45 (0.23, 0.86) | 0.56 (0.26, 1.20) | 0.40 (0.18, 0.88) | 0.48 (0.19, 1.22) | 0.34 (0.14, 0.84) | 0.47 (0.28, 0.81) | 0.63 (0.30, 1.30) | 0.77 (0.38, 1.55) | 1.03 (0.5, 2.12) | 0.92 (0.44, 1.93) | 0.89 (0.43, 1.84) |
Men | 0.22 (0.09, 0.53) | 0.30 (0.11, 0.84) | 0.13 (0.04, 0.41) | 0.27 (0.09, 0.87) | 0.19 (0.06, 0.59) | 0.38 (0.19, 0.72) | 0.52 (0.22, 1.23) | 0.68 (0.3, 1.55) | 0.94 (0.36, 2.47) | 0.68 (0.26, 1.78) | 0.70 (0.27, 1.81) |
Women | 1.58 (0.44, 5.69) | 1.39 (0.32, 6.14) | 2.17 (0.53, 8.91) | 1.43 (0.19,11.0) | 0.74 (0.09, 5.81) | 0.72 (0.27, 1.88) | 1.9 (0.36, 9.96) | 0.49 (0.09, 2.61) | 1.11 (0.33, 3.72) | 0.9 (0.23, 3.56) | 0.47 (0.11, 2.14) |
Insulin resistance measured by HOMA-IR, triglycerides index, and McAuley index among men and women in the NOAH Study. All models were adjusted by education, race, BMI, smoking status, viral load, CD4 count, protease inhibitor use, use of statins or metformin, physical activity, and diabetes diagnosis.
Bold values represent higher or lower odds ratio that are statistically significant.
NOAH, New Orleans Alcohol Use in HIV.