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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Wiley Interdiscip Rev RNA. 2020 Jan 23;11(3):e1581. doi: 10.1002/wrna.1581

Figure 3. HuR as a sensitizer.

Figure 3

HuR inhibition has been used as a successful means to sensitize cancer calls. Standard of care chemotherapeutics cause damage which activates HuR causing a rapid response and stabilization of pro-survival mRNA. This leads to cell survival and chemotherapeutics resistance. Inhibition of HuR in response to DNA damaging agents can be accomplished through either inhibition of HuR expression (here shown with siRNA carrying nanoparticles), HuR translocation (here shown with pyrvinium), or target binding (here shown with DHTS), all of which would in this case lead to the loss of regulation of targets such as PIM1 or CDC6 and enhanced cell sensitivity.