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. Author manuscript; available in PMC: 2020 Sep 10.
Published in final edited form as: Pharmacoepidemiol Drug Saf. 2018 Apr 26;28(1):16–24. doi: 10.1002/pds.4445

TABLE 1.

Characteristics of cohort of beneficiaries enrolled in the North Carolina Medicaid “lock-in” program, October 2009-June 2013, and by latent class of log average daily morphine milligram equivalents (MMEs) of dispensed opioid trajectories

Total Cohort
(n=2,701)
Start high, end high (C1)
(n=353.0; 13.1%)
Start medium, end medium (C2)
(n=357.6; 13.2%)
Start medium, end low (C3)
(n=581.3; 21.5%)
Start low, end medium (C4)
(n=609.4; 22.6%)
Start low, end low (C5)
(n=799.8; 29.6%)
N (%) for categorical variables; Mean (25th pct, median, 75th pct) for continuous variables
DEMOGRAPHICS
Age (years) 38.7 (30, 38, 47) 43.6 (37, 44, 52) 43.6 (36, 44, 51) 39.5 (31, 39, 47) 38.6 (31, 38, 46) 33.9 (27, 32, 40)
Gender
 Women 1,896 (70.2) 216.2 (61.3) 233.3 (65.3) 386.9 (66.6) 446.3 (73.2) 613.3 (76.7)
 Men 805 (29.8) 136.8 (38.8) 124.2 (34.7) 194.4 (33.4) 163.1 (26.8) 186.5 (23.3)
Race
 White 1,999 (74.0) 268.0 (75.9) 246.4 (68.9) 424.8 (73.1) 433.4 (71.1) 626.4 (78.3)
 Black 550 (20.4) 66.9 (19.0) 86.3 (24.1) 116.6 (20.1) 133.6 (21.9) 146.5 (18.3)
 Other 152 (5.6) 18.0 (5.1) 24.9 (7.0) 39.9 (6.9) 42.3 (7.0) 26.9 (3.4)
Urbanicity of county of residence
 Counties in metro areas of ≥ 1 mill. pop. 675 (25.0) 65.9 (18.7) 86.1 (24.1) 137.5 (23.7) 161.4 (26.5) 224.1 (28.0)
 Counties in metro areas of < 1 mill. pop. 1,268 (47.0) 180.8 (51.3) 162.3 (45.4) 269.7 (46.4) 276.9 (45.4) 378.3 (47.3)
 Nonmetro, urban pop. of ≥ 20,000 444 (16.4) 54.2 (15.4) 73.3 (20.5) 102.8 (17.7) 111.7 (18.3) 102.0 (12.8)
 Nonmetro, urban pop. of <20,000 or rural pop. 314 (11.6) 51.9 (14.7) 35.9 (10.1) 71.4 (12.3) 59.3 (9.7) 95.4 (11.9)
Medicaid eligibility category
 Aid to families with dependent children 1,389 (51.4) 119.4 (33.8) 135.5 (37.9) 267.0 (45.9) 347.9 (57.1) 519.2 (64.9)
 Aid to disabled 1,282 (47.5) 232.5 (65.9) 219.0 (61.3) 311.2 (53.5) 259.6 (42.6) 259.7 (32.5)
 Aid for other reasons (e.g., aid to blind) 30 (1.1) 1 (0.3) 3.0 (0.8) 3.2 (0.6) 1.9 (0.3) 20.9 (2.6)
SUBSTANCE USE-RELATED§
 Alcohol-related disorder 174 (6.4) 18.5 (5.3) 30.8 (8.6) 38.4 (6.6) 35.0 (5.7) 51.2 (6.4)
 Other substance-related disorder 870 (32.2) 110.3 (31.2) 82.7 (23.1) 214.7 (36.9) 171.9 (28.2) 290.4 (36.3)
 Medication-assisted treatment (MAT) 273 (10.1) 7.5 (2.1) 4.1 (1.1) 43.8 (7.5) 37.7 (6.2) 180.0 (22.5)
 Medication or drug-related overdose 193 (7.2) 29.8 (8.4) 23.1 (6.5) 58.2 (10.0) 33.0 (5.4) 49.0 (6.1)
HEALTH CARE UTILIZATION §
 Number of unique pharmacies from which
 Medicaid-reimbursed prescriptions were
 obtained
4.2 (2, 4, 6) 3.7 (2, 3, 5) 4.0 (2, 4, 5) 4.4 (3, 4, 6) 4.3 (3, 4, 6) 4.2 (3, 4, 5)
 Emergency department visits 9.9 (3, 6, 13) 5.5 (1, 3, 7) 9.4 (2, 5, 12) 10.8 (3, 7, 14) 10.3 (3, 7, 13) 11.3 (4, 8, 14)
 Inpatient admissions 1.3 (0, 1, 2) 1.6 (0, 1, 2) 1.5 (0, 1, 2) 1.6 (0, 1, 2) 1.2 (0, 1, 2) 1.0 (0, 1, 1)
PAIN-RELATED DIAGNOSES §
 Any joint pain or arthritis 2,452 (90.8) 325.4 (92.2) 338.9 (94.8) 549.3 (94.5) 571.7 (93.8) 666.7 (83.4)
 Back pain 2,253 (83.4) 308.4 (87.4) 309.0 (86.4) 504.3 (86.8) 535.0 (87.8) 596.3 (74.6)
 Neck pain 1,124 (41.6) 141.4 (40.1) 165.4 (46.3) 252.9 (43.5) 277.3 (45.5) 287.1 (35.9)
 Headache/migraine pain 589 (21.8) 63.3 (17.9) 80.1 (22.4) 131.6 (22.6) 146.5 (24.0) 167.5 (21.0)
 Fibromyalgia, chronic pain, or fatigue 1,443 (53.4) 261.1 (74.0) 230.8 (64.5) 363.1 (62.5) 353.5 (58.0) 234.6 (29.3)
 Rheumatoid arthritis or osteoarthritis 706 (26.1) 144.5 (41.0) 139.0 (38.9) 168.0 (28.9) 160.0 (26.3) 94.4 (11.8)
 Sickle cell 50 (1.9) 17.3 (4.9) 9.8 (2.7) 11.7 (2.0) 10.0 (1.6) 1.2 (0.2)
MENTAL HEALTH-RELATED DIAGNOSES §
 Depression 1,675 (62.0) 193.6 (54.9) 221.6 (62.0) 364.0 (62.6) 388.0 (63.7) 508.8 (63.5)
 Anxiety disorder 1,184 (43.8) 123.2 (34.9) 136.6 (38.2) 288.6 (49.6) 275.7 (45.2) 360.0 (45.0)
 Other serious mental health disorder (e.g., bipolar, schizophrenia) 751 (27.8) 59.5 (16.9) 71.6 (20.0) 189.1 (32.5) 172.9 (28.4) 257.9 (32.3)
COMORBID CONDITION INDEX§
 Mean Charlson comorbidity index 0.92 (0, 0, 1) 1.31 (0, 1, 2) 1.20 (0, 1, 2) 0.98 (0, 0, 1) 0.93 (0, 0, 1) 0.57 (0, 0, 1)

pct= percentile; C= class

Counts, percentages, and means are weighted by beneficiaries’ posterior probabilities for belonging to a given class

Assessed at the time of “lock-in” program enrollment

§

Assessed using a one-year lookback period from the date of “lock-in” program enrollment