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. 2020 May 9;19(Suppl 1):34–42.
Intervention Vitamin D
Suggested dose 5,000 IU po qd in the absence of serum levels
Mechanism(s) of action against non-COVID-19 viruses55-78 Favorably modulate cellular defense and repair mechanisms:
  • Activation of macrophages

  • Stimulation of anti-microbial peptides

  • Modulation of defensins

  • Modulation of TH17 cells

Favorably modulate viral-induced pathological cellular processes:
  • Reduction in cytokine expression

  • Modulation of TGF beta

Outcomes data supporting their mitigating effects on illness from other viral strains Reduce progression from colonization to illness
Reduce the severity and duration of acute symptoms and complications
Strength of evidence Limited
Risk of harm79-82 Mimimal