Strength of Evidence	Risk of Harm
Strength of Evidence Conditional Clinical experience and/or expert opinion and/or conflicting studies; biological mechanism at least partly explained.	Risk of Harm Mimimal Risk of self-limited symptoms; no risk of loss of function or corrective intervention anticipated; observation only.
Strength of Evidence Limited One study showing correlation between intervention and outcome; compelling ATMs and/or PCFs; biological mechanism at least partly explained.	Risk of Harm Mild Risk of symptoms; no risk of loss of function or quality of life; minor evaluative and/or therapeutic intervention needed.
Strength of Evidence Moderate Two independent studies (one of which is LOE = 1 or 2) showing correlation between intervention and outcome; biological mechanism at least partly explained.	Risk of Harm Significant Risk of temporary loss of function or quality of life; significant evaluative and/or therapeutic intervention needed.
Strength of Evidence Strong Two independent studies (both LOE = 1 or 2) showing correlation between intervention and outcome; biological mechanism fully explained or partly explained and having one additional correlative study.	Risk of Harm Severe Risk of permanent symptoms, loss of function, quality of life, or death; long-term evaluative and/or therapeutic intervention needed.

Note: This resource is only intended to identify botanical and nutraceutical and botanical agents that may boost your immune system. It is not meant to recommend any treatments, nor have any of these been proven effective against coronavirus. None of these practices are intended to be used in lieu of other recommended treatments. Always consult your physician or healthcare provider prior to initiation. For up-to-date information on COVID-19, please consult the Centers for Disease Control and Prevention at www.cdc.gov.