Table 2.
Genetic characteristics of rectal cancer patients with or without preoperative chemoradiation
| Case | Preoperative therapy | Duration (days) | SNV (exon) | SNV (nonsynonymous) | Driver gene mutations | TMB (mutations/Mb) | CNV size (Mb) | Tumor content (%) |
|---|---|---|---|---|---|---|---|---|
| REC-001 | CRT | 86 | 9 | 6 | None | 0.122 | 2.27 | 18.5 |
| REC-002 | CRT | 42 | 3 | 1 | None | 0.091 | 175.9 | 93.5 |
| REC-003 | CRT | 41 | 4 | 1 | None | 0.06 | 66.4 | 23.4 |
| REC-004 | CRT | 50 | 7 | 5 | None | 0.091 | 14.6 | 18.4 |
| REC-005 | CRT | 56 | 9 | 8 | None | 0.12 | 131.5 | 19.2 |
| REC-006 | CRT | 42 | 7 | 5 | LMO1 | 0.06 | 833.2 | 20.4 |
| REC-007 | CRT | 47 | 11 | 8 | None | 0.325 | NA | NA |
| REC-008 | CRT | 43 | 19 | 13 | None | 0.565 | NA | NA |
| REC-009 | CRT | 56 | 4 | 3 | None | 0.117 | NA | NA |
| REC-010 | - | - | 65 | 38 | APC, NOTCH1, NOTCH2, TP53 | 1.982 | 2447 | 68.6 |
| REC-011 | - | - | 101 | 65 | APC, FBXW7, KRAS | 3.249 | 655.5 | 47.1 |
| REC-012 | - | - | 107 | 73 | BRAF, TP53 | 3.025 | 611.5 | 53.8 |
| REC-013 | - | - | 146 | 108 | APC, CREBBP, TP53 | 4.371 | 2545 | 28.5 |
| REC-014 | - | - | 155 | 107 | APC, BRCA2, KRAS | 4.702 | 835.0 | 36.1 |
| REC-015 | - | - | 144 | 89 | APC, FBXW7, KRAS, TP53 | 4.399 | 785.3 | 39.6 |
| REC-016 | - | - | 94 | 61 | APC, BRAF, PTEN | 2.845 | 1087 | 27.4 |
| REC-017 | - | - | 70 | 47 | TP53 | 2.136 | 1700 | 33.7 |
| REC-018 | - | - | 79 | 52 | AMER1, APC, KDM6A, KMT2C, TP53 | 2.238 | 1874 | 83.3 |
| REC-019 | - | - | 80 | 54 | APC, ATM, KRAS, PTEN | 2.41 | 1668 | 47.5 |