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. 2020 Aug 24;375(1809):20190660. doi: 10.1098/rstb.2019.0660

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© 2020 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 2. — Modelling Shh-controlled gene expression. (a) (i) Key feedbacks present in the model in [66]. (ii) Bifurcation analysis of the model in [66]. The model exhibits bistability, demonstrating that a graded input of Shh can result in a binary response. (b) (i) Example of transverse section of the developing neural tube, molecularly labelled for genes that indicate DV identity, from [67]. (ii) Experimental measurements of Shh levels from [68]. (iii, iv) Fitting of the data to the mathematical model in [68], with high (upper) and low (lower) expression of Shh. a.u., arbitrary units.