Figure 3.

EMP occurs along branched trajectories to produce divergent cell fates. The extent to which EMT is activated, and the nature of the epithelial cell in which EMT is induced, results in a broad spectrum of partial EMT states. However, given that MET is not simply the reversal of the EMT process, the end result of this programme is not a reversion to the initial epithelial state (yellow with black nucleus) but the adoption of a second, distinct epithelial cell fate (yellow with red nucleus). It is worth noting that, though the arrows in this diagram indicate a complete progression through to a fully mesenchymal state prior to MET, it is also possible for cells exhibiting a partial EMT to undergo MET towards a second epithelial state, effectively bypassing full EMT.